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FLASH GENE
Symbol LIPI contributors: mlc - updated : 13-06-2007
HGNC name lipase, member I
HGNC id 18821
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Lpdl ( 71 p 100)
Homologene
FAMILY
  • AB hydrolase superfamily
  • lipase family
  • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • hydrolyzing specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with heparin with a high affinity
  • cell & other
    REGULATION
    inhibited by sodium vanadate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    heterozygous C55Y in 2 Caucasians with moderate to severe hypertriglyceridemia (145750)
    Susceptibility to hypertriglyceridemia
    Variant & Polymorphism other DNA variant, namely 164G>A (C55Y), in hypertriglyceridemia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS