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FLASH GENE
Symbol AHSA1 contributors: - updated : 15-12-2006
HGNC name AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
HGNC id 1189
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to chimpanzee AHSA1 (99.7pc)
homolog to murine Ahsa1 (95.0pc)
homolog to chicken AHSA1 (77.2pc)
Homologene
FAMILY AHA1 family
CATEGORY chaperone/stress , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • affecting cargo movement at the step of ER to Golgi traffic
  • activating the ATPase activity of HSP90 and modulating the stability of CFTR
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to VSVG (vesicular stomatitis virus glycoprotein)
  • interacting with HSP90
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS