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FLASH GENE
Symbol ASGR2 contributors: npt/ - updated : 08-03-2006
HGNC name asialoglycoprotein receptor 2
HGNC id 743
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-type lectin family domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Asgr2
    homolog to C.elegans B0218.6
    intraspecies homolog to ASGR1
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • transporting these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates
  • asialoglycoprotein receptor
  • mediating galactose-terminated glycoproteins endocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    text endocytosis of galactose-terminated glycoproteins (plasma glycoproteins)
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • functioning ligand-binding unit thought to be at least a dimer
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to galactose-terminated glycoproteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS