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FLASH GENE
Symbol CRIP2 contributors: mct - updated : 28-01-2012
HGNC name cysteine-rich protein 2
HGNC id 2361
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich motifs
  • two LIM zinc-binding domains
  • lacks the DNA-binding LIM domain
  • HOMOLOGY
    interspecies homolog to rattus Esp1or CRP2
    Homologene
    FAMILY
  • cysteine-rich intestine protein family l and specifically to the second class of LIM domain proteins
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,nucleus
    text
  • in the cardiomyocytes, colocalized with cardiac troponin T in the thin-filaments of sarcomeres
  • predominantly localized in the cytoplasm of olfactory precursor cells
  • expressed in the nucleus
  • basic FUNCTION
  • involved in transcription
  • acting as a regulator of alpha-actinin function
  • acts as a transcription repressor of the NFKB–mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis
  • functional role of CRIP2 in cancer development and crucial role in regulating angiogenesis during tumor development
  • regulates NFKB transcriptional activity by inhibiting its binding to the promoter region
  • might exert an important impact on the cardiovascular development, maintenance and homeostasis
  • play an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • interacting with WNT3A (WNT3A regulates the development of cardiac neural crest cells by modulating expression of CRIP2 in rhombomere 6)
  • association with ADAM19 through its disintegrin (DI) domain, a cysteine-rich (Cys) domains (ADAM19 promotes the secretion of CRIP2)
  • cell & other
    REGULATION
    Other regulation of CRIP2 localization by the development of actin fibers during smooth muscle cell differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL14QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    induces apoptosis through induction of active caspases 3 and 9 proteins in esophageal squamous cell carcinoma
    tumoral     --low  
    in nasopharyngeal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene for ID in del14qter
    Marker
    Therapy target
    ANIMAL & CELL MODELS