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FLASH GENE
Symbol TNNT3 contributors: mct - updated : 12-04-2014
HGNC name troponin T type 3 (skeletal, fast)
HGNC id 11950
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • both a nuclear localization signal
  • and a DNA-binding domain, which may mediate nuclear/nucleolar signaling and muscle cell apoptosis
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Tnnt3
    homolog to C.elegans Y49F6B.2
    Homologene
    FAMILY
  • troponin T family
  • CATEGORY motor/contractile , regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the attachment of the complex to tropomyosin and troponin I
  • involved in the regulation of striated muscle contraction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , locomotion
    text fast skeletal muscles development
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the troponin complex forming the calcium-sensitive molecular switch that regulates striated muscle contraction in response to modifications in intracellular concentration
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to tropomyosin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCD2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • aberrant TNNT3 represents a biological marker of muscle phenotype severity and disease progressionin FSHMD1A
  • Therapy target
    ANIMAL & CELL MODELS