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FLASH GENE
Symbol PTP4A3 contributors: mct - updated : 19-09-2017
HGNC name protein tyrosine phosphatase type IVA, member 3
HGNC id 9636
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PTP domain
  • one C terminal prenylation motif
  • HOMOLOGY
    interspecies homolog to murine ptp4a3
    intraspecies homolog to PRL1
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • CATEGORY regulatory , receptor membrane G tyrosine phosphatase
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • play regulatory roles in a variety of cellular processes
  • protein tyrosine phosphatase associated with tumor metastasis
  • promotes cancer metastasis through enhanced cell motility and invasiveness
  • is a novel regulator of NFKB1 signaling pathway through TERF2IP
  • PTP4A1, PTP4A2, PTP4A3 are key contributors to metastasis in several human cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • down-regulate the tyrosine-phosphorylation level of integrin beta1 (ITGA1) and increased the phosphorylation level of Erk1/2
  • inverse correlation between protein levels of PTP4A3 and PCBP1 in human primary cancers
  • Stathmin, a key oncoprotein, is a new PTP4A3 associated protein (both contributed to microtubule (MT) destabilization of colorectal carcinoma cells)
  • FKBP8 is an interacting protein of PTP4A3
  • interacts with telomere-related protein TERF2IP
  • LEO1 is a novel and important mediator of PTP4A3 oncogenic activities in Acute Myeloid Leukemia (AML)
  • PTP4A3 binds to the RNA helicase DDX21, thereby restricting productive transcription by RNAPII at master transcription factor (MITF)-regulated endolysosomal vesicle genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal tumor with metastases
    tumoral     --over  
    in various cancers, such as colorectal cancer, gastric cancer, and ovarian cancer, and is correlated with the progression and survival of cancers
    tumoral     --over  
    is a frequent event associated with lymph node metastasis (LNM) and plays a causative role in promoting cancer progression (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    may constitute a useful marker for metastasis and might be a new therapeutic target
    cancerdigestivecolon
    act as a promising biomarker for individualized therapy for patients with colonic cancer, especially for those diagnosed at an early stage.
    cancerdigestiveoesophagus
    could be a convergent therapeutic target against esophageal squamous cell carcinoma (ESCC) with lymph node metastasis (PMID: 19960436)
    ANIMAL & CELL MODELS