protein
| down-regulate the tyrosine-phosphorylation level of integrin beta1 (ITGA1) and increased the phosphorylation level of Erk1/2 |
|
inverse correlation between protein levels of PTP4A3 and PCBP1 in human primary cancers |
|
Stathmin, a key oncoprotein, is a new PTP4A3 associated protein (both contributed to microtubule (MT) destabilization of colorectal carcinoma cells) |
|
FKBP8 is an interacting protein of PTP4A3 |
|
interacts with telomere-related protein TERF2IP |
|
LEO1 is a novel and important mediator of PTP4A3 oncogenic activities in Acute Myeloid Leukemia (AML) |
|
PTP4A3 binds to the RNA helicase DDX21, thereby restricting productive transcription by RNAPII at master transcription factor (MITF)-regulated endolysosomal vesicle genes |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in colorectal tumor with metastases | tumoral
|  
|  
| --over
|  
|
in various cancers, such as colorectal cancer, gastric cancer, and ovarian cancer, and is correlated with the progression and survival of cancers | tumoral
|  
|  
| --over
|  
|
is a frequent event associated with lymph node metastasis (LNM) and plays a causative role in promoting cancer progression ( | |