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FLASH GENE
Symbol RAB21 contributors: mct/npt - updated : 11-03-2016
HGNC name RAB21, member RAS oncogene family
HGNC id 18263
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies homolog to Drosophila CG7646
homolog to C.elegans ncs-2
Homologene
FAMILY
  • RAS superfamily
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • associated with the Golgi apparatus
  • ANKRD27, VAMP7 and RAB21 co-localize in the perinuclear region of differentiating hippocampal neurons and transiently in transport vesicles in the shaft of neurites
  • basic FUNCTION
  • playing a role in the regulation of vesicular transport in polarized intestinal epithelial cells
  • regulates cell adhesion and controls endosomal traffic of beta1-integrins
  • regulating endo/exocytic trafficking of integrins (
  • RAB21 activity, integrin-RABb21 association, and integrin endocytosis are all necessary for normal cytokinesis, which becomes impaired when integrin-mediated adhesion at the cleavage furrow fails
  • RAB21-regulated integrin trafficking is essential for normal cell division, and its defects may contribute to multinucleation and genomic instability, which are hallmarks of cancer
  • regulates SSTR3 trafficking, suggesting that it may play a role in trafficking of other G protein-coupled receptors
  • enhanced the degradation of EGFR through accelerating its internalization in both EGF-independent and EGF-dependent manners
  • plays a negative role in the EGF-mediated MAPK signaling pathway (
  • regulates the dynamic process of sorting cargoes from early endosomes to late endosomes/lysosomes
  • SBF2 and RAB21 have conserved functions required for starvation-induced autophagy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • interacting with ANKRD27 (functions as a Guanine nucleotide exchange factor for RAB21)
  • interacting with the cytoplasmic domains of alpha-integrin chains, and its expression influences the endo/exocytic traffic of integrins
  • RASA1 interacted with the cytoplasmic domain of integrin alpha-subunits via its GAP domain and competed with RAB21 for binding to endocytosed integrins
  • SBF2 is a critical coordinator of PI(3)P and RAB21 regulation, which specifies an endosomal pathway and cortical control
  • SBF2 is required for RAB21 activation, VAMP8 interaction and VAMP8 endolysosomal trafficking, defining a novel GEF-Rab-effector pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS