SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
text
| associated with the Golgi apparatus |
|
ANKRD27, VAMP7 and RAB21 co-localize in the perinuclear region of differentiating hippocampal neurons and transiently in transport vesicles in the shaft of neurites |
basic FUNCTION
| playing a role in the regulation of vesicular transport in polarized intestinal epithelial cells |
|
regulates cell adhesion and controls endosomal traffic of beta1-integrins |
|
regulating endo/exocytic trafficking of integrins ( |
|
|
|
RAB21 activity, integrin-RABb21 association, and integrin endocytosis are all necessary for normal cytokinesis, which becomes impaired when integrin-mediated adhesion at the cleavage furrow fails |
|
RAB21-regulated integrin trafficking is essential for normal cell division, and its defects may contribute to multinucleation and genomic instability, which are hallmarks of cancer |
|
regulates SSTR3 trafficking, suggesting that it may play a role in trafficking of other G protein-coupled receptors |
|
enhanced the degradation of EGFR through accelerating its internalization in both EGF-independent and EGF-dependent manners |
|
plays a negative role in the EGF-mediated MAPK signaling pathway ( |
|
regulates the dynamic process of sorting cargoes from early endosomes to late endosomes/lysosomes |
|
SBF2 and RAB21 have conserved functions required for starvation-induced autophagy |