SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule
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text
| associates with primary cilia in renal epithelia |
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RAB10 localizes to the ER and to dynamic ER-associated structures that track along microtubules and mark the position of new ER tubule growth |
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RAB10 colocalized with HAS3 in intracellular vesicular structures and was co-immunoprecipitated with HAS3 from isolated endosomal vesicles |
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subcellular localizations include the endoplasmic reticulum (ER), Golgi/TGN, the endosomes/phagosomes and the primary cilia (pMID: 29377137) |
basic FUNCTION
| involved in vesicular trafficking and neurotransmitter release |
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having functions in trafficking from the Golgi at early stages of epithelial polarization, is involved in biosynthetic transport to the basolateral membrane and may co-operate with RAB8 |
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implicated in insulin-stimulated SLC2A4 translocation |
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small GTPase which is essential for optimal macrophage activation following lipopolysaccharide stimulation |
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its expression provides a mechanism to refine TLR4 signaling by regulating the trafficking rate of TLR4 onto the plasma membrane |
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RAB10 and EHBP1 function together in many cell types, suggesting that there are differences in the level of redundancy among Rab family members in polarized versus nonpolarized cells |
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RAB10 is likely involved in insulin-stimulated translocation of SLC2A4 storage vesicle (GSV) to the Plasma membrane, with RAB14 involved in insulin-stimulated translocation of SLC2A4-containing endosome |
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is an ER-specific Rab GTPase that regulates ER structure and dynamics |
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MIA3 and RAB10 are planar polarized at the basal epithelial surface |
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novel function for RAB10 in reducing cell surface HAS3, suppressing hyaluronan (HA) synthesis, and facilitating cell adhesion to type I collagen |
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RAB10 promotes likely the ability of endosome-bound EHBP1 to also bind to the actin cytoskeleton, thereby promoting endosomal tubulation |
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is a regulator of insulin-stimulated translocation of the SLC2A4 glucose transporter to the plasma membrane (PM) of adipocytes, which is essential for whole-body glucose homeostasis |
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SEC16A and RAB10 promote insulin-stimulated mobilization of SLC2A4 from a perinuclear recycling endosome/TGN compartment |
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regulates cell survival and proliferation through multiple oncogenic, cell stress and apoptosis pathways |
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RAB10 has been implicated in a myriad of activities ranging from polarized exocytosis and endosomal sorting in polarized cells, insulin-dependent SLC2A4 transport in adipocytes, axonal growth in neurons, and endo-phagocytic processes in macrophages |
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RAB10 and RAB18 were reported to control ER shape by regulating ER dynamics and fusion |
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small Rab GTPase involved in vesicular trafficking |
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stress-responsive machinery composed of RAB29, LRRK2, phosphorylated RAB8/RAB10, and their downstream effectors implicated in the maintenance of lysosomal homeostasis |