Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PTBP2 contributors: mct/pgu - updated : 20-03-2020
HGNC name polypyrimidine tract binding protein 2
HGNC id 17662
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four RNA recognition motifs (RRM)
conjugated sumoylated
HOMOLOGY
interspecies ortholog to murine Ptbp2
homolog to Drosophila CG8831
intraspecies homolog to PTB
homolog to SNRP70
Homologene
FAMILY PTB (polypyrimidine tract-binding )protein family
CATEGORY regulatory , RNA associated , antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
text
  • in the spliceosome
  • is a nucleocytoplasmic shuttle protein
  • basic FUNCTION
  • involved in controling the assembly of other splicing-regulatory proteins
  • enhancing the binding of two other proteins (hnRNPH and KSRP) to the DCS RNA
  • possible retinal autoantigen of cancer-associated retinopathy (CAR)
  • potential trans-acting factor that helps to stabilize PGK2 mRNA in male germ cells
  • post-transcriptional switch from PTBP1 to PTBP2 controls a widespread alternative splicing program during neuronal development
  • promoting pre-mRNA 3' end processing in collaboration with hnRNPH
  • PTBP1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by PTBP2
  • potential role for PTBP2 in neurogenesis
  • PTBP1 and its brainspecific homologue, PTBP2, are associated with pre-mRNAs and influence pre-mRNA processing, as well as mRNA metabolism and transport
  • controls a genetic program essential for neuronal maturation
  • PTBP2 is required for alternative splicing regulation in the testis, as in brain
  • functions as a key regulator of alternative pre-mRNA splicing in the nucleoplasm and promotes internal ribosome entry site-mediated translation initiation of viral and cellular mRNAs in the cytoplasm
  • PTBP1 and PTBP2, are also nonconserved cryptic exon repressors and PTBP1 and PTBP2, are also nonconserved cryptic exon repressors, and PTBP1 and PTBP2 are members of a family of cryptic exon repressors
  • PTBP1 and PTBP2 reprogram developmental pre-mRNA splicing in neurons
  • PTBP1 and PTBP2 serve both specific and redundant functions in neuronal pre-mRNA splicing
  • PTBP2 controls a network of genes involved in cell adhesion, migration, and polarity, suggesting that splicing regulation by PTBP2 is critical for germ cell communication with Sertoli cells
  • is a key alternative splicing regulator for male germ cell development
  • is an essential factor in heat stress-induced sperm cell injury and non-obstructive azoospermia
  • necessary and sufficient to convert non-neuronal cells to the neuronal lineage
  • is a new possible target for chronic myeloid leukemia (CML) and progressive inclusion/exclusion of PTBP2 exon 10 might play an important role in CML progression
  • PTBP2-orchestrated alternative splicing programming is required for robust generation of a single axon in mammals
  • PTBP1, PTBP2 are essential for B cell development
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation of hematopoietic cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS)
  • binding to the HBB 3'UTR
  • small molecule
    protein
  • TP53 internal ribosome entry sites (IRES) interacting trans-acting factor (PTBP2 binds specifically to both the TP53 IRESs but with differential affinity)
  • CELF1 interacts with PTB proteins (PTBP1, PTBP2) (CELF1 and PTB proteins modulate the inclusion of TPM2 exon 6B during myogenic differentiation)
  • interacts with AICDA (PTBP2 is thus an effector of class-switch recombination that promotes the binding of AICDA to switch-region DNA)
  • re-expression of PTBP1 or PTBP2 in differentiated neurons inhibited DLG4 expression and impaired the development of glutamatergic synapses
  • cell & other
    REGULATION
    Other PTBP2 is posttranslationally modified by SUMO1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS