Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AP4S1 contributors: mct/ - updated : 06-07-2011
HGNC name adaptor-related protein complex 4, sigma 1 subunit
HGNC id 575
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
interspecies homolog to murine Ap4s1
homolog to C.elegans T20B5.1
Homologene
FAMILY adaptor complexes medium subunit family
CATEGORY adaptor , transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text associated with trans Golgi network
basic FUNCTION
  • involved in recognition and sorting of cargo proteins with tyrosine-based motifs
  • involved in targeting proteins from the trans Golgi network to the endosomal-lysosomal system
  • crucial role of AP4-mediated trafficking in brain development and functioning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    text non selective vesicle and coated vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
  • submit of an adaptator-like heterotetrameric (AP-4) complex composed of two large chains (epsilon/AP4E1 and beta/AP4B1),a medium chain (MU/AP4M1) and a small chain (sigma AP4S1)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG52
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS