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FLASH GENE
Symbol ARFGAP2 contributors: mct/npt - updated : 13/09/2008
HGNC name ADP-ribosylation factor GTPase activating protein 2
HGNC id 13504
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila aef1
    homolog to yeast gcs-1
    homolog to C.elegans C55B7.12
    ortholog to murine Znf289
    ortholog to yeast Glo3p
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    text predominantly cytoplasmic
    basic FUNCTION
  • mediator of ID1 induced proliferation pathway in mammary epithelial cells
  • ARFGAP2 and ARFGAP3 are coat protein-dependent ArfGAPs
  • control guanosine triphosphate (GTP) hydrolysis on the small G protein ADP-ribosylation factor ARF1 at the Golgi apparatus
  • ARFGAP1, ARFGAP2, and ARFGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport
  • function with ARFGAP2 in COP I traffic
  • follow the dynamic behavior of coatomer upon stimulation of vesicle budding
  • ARFGAP2 and ARFGAP3 seem to be essential for the formation of the vesicle promoting coat lattice
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    activated by ID1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS