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FLASH GENE
Symbol UPF3A contributors: mct - updated : 03-10-2017
HGNC name UPF3 regulator of nonsense transcripts homolog A (yeast)
HGNC id 20332
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Smg4/UPF3 domain
  • one RNA recognition motif (RRM)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to Drosophila BG:DS07851.3
    homolog to C.elegans C23q10.2
    ortholog to murine Upf3a
    intraspecies homolog to sequences found in the SMS repeat gene clusters SMS-REPD,SMS-REPM,SMS-REPP (see symbols) and UPF3A1,UPF3AP1,UPF3AP2
    paralog to UPF3B
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • key factor in both mRNA nuclear export and mRNA surveillance for the deletion of truncated messengers and initiation of nonsense mediated mRNA decay (NMD)
  • mediating the splicing of pre-mRNA by binding to the loop I region of U1-snRNA
  • acting as a nucleocytoplasmic shuttle
  • UPF3A levels are tightly regulated by a post-transcriptional switch to maintain appropriate levels of NMD substrates in cells containing different levels of UPF3B
  • UPF3B--is critical for the nonsense-mediated RNA decay (NMD) pathway, while its autosomal counterpart--UPF3A--encodes an enigmatic protein previously shown to have trace NMD activity
  • likely UPF3A acquired repressor activity through simple impairment of a critical domain, a rapid mechanism that may have been widely used in evolution
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a post-splicing multiprotein complex
    INTERACTION
    DNA
    RNA binding specifically to 20nt upstream of exon-exon junctions in mRNAs
    small molecule
    protein
  • RBM8A, THOC4 (ALY), NXF1 (TAP), UPF2
  • ability of UPF1 to impinge on premature termination, moreover, requires ATP-binding, RNA-binding and NMD cofactors UPF2 and UPF3A, UPF3B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS