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FLASH GENE
Symbol MIOX contributors: mct/npt - updated : 15-04-2020
HGNC name myo-inositol oxygenase
HGNC id 14522
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Aldrl6
homolog to Drosophila mRpS7
Homologene
FAMILY
  • myo-inositol oxygenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • non-heme iron enzyme, catalyzing the oxidative cleavage of myo-inositol to give D-glucuronic acid, a committed step in myo-inositol catabolism
  • MIOX catalyzes the oxidative cleavage of myo-inositol (MI) to give D-glucuronic acid, a committed step in MI catabolism
  • tubular-specific enzyme, modulating redox imbalance and apoptosis in tubular cells in diabetes
  • epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy
  • MIOX expression profile modulates pathogenic ferroptosis in the renal proximal tubule
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    myo-inositol catabolism pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • high fat diet (HFD) or fatty acids modulate transcriptional, translational, and post-translational regulation of MIOX expression/activity and underscore MIOX being a novel target of the transcription factor SREBF1
    • cell & other
    REGULATION
    activated by a positive feedback mechanism where xylitol, one of the products of myo-inositol catabolism via the glucuronate-xylulose pathway, induces an overexpression of MIOX
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    drives the progression of renal tubulo-interstitial injury in diabetes
    constitutional     --over  
    in diabetic kidneys may contribute to tubulointerstitial injury and the development of diabetic nephropathy
    Susceptibility to Type 1 diabetes mellitus
    Variant & Polymorphism other
  • polymorphism (rs761745) in the promoter region of MIOX gene may be associated with the development of T1D
    • Candidate gene
    Marker
  • MIOX levels were higher in gestational diabetes mellitus (GDM) cases so, it may be have a role in myo-inositol catabolism
  • potential use of MIOX as a kidney-specific enzyme in the early diagnosis of acute kidney injury (AKI)
  • concentration of MIOX in the serum and urine may serve as a new biomarker for the early diagnosis of diabetic nephropathy (DN)
    • Therapy target
    ANIMAL & CELL MODELS
  • expression of MIOX was increased at both the mRNA and protein levels in the kidney of rats with diabetic nephropathy
  • in tubules of diabetic mice, increased MIOX expression and mitochondrial fragmentation and defective autophagy were observed