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FLASH GENE
Symbol ACTR2 contributors: mct - updated : 09-07-2019
HGNC name ARP2 actin-related protein 2 homolog (yeast)
HGNC id 169
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer
HOMOLOGY
interspecies homolog to Drosophila Arp14D
homolog to C.elegans K17C5.1
ortholog to Actr2, Mus musculus
homolog to yeast S.cerevisiae arp2
ortholog to Actr2, Rattus norvegicus
ortholog to ACTR2, Pan troglodytes
Homologene
FAMILY
  • actin family
  • ARP2 subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text actin cytoskeleton associated
    basic FUNCTION
  • being essential to cell shape and motility through lamellipodial actin assembly and protrusion
  • ACTR2/ACTR3 is a major nucleator of actin assembly at the zonula adherens (ZA)
  • close relationship exists between ACTR2/ACTR3-mediated actin assembly and myosin-driven contractility at the ZA
  • WASF2–ACTR2/ACTR3 is necessary for myosin II recruitment and tension generation at the zonula adherens
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component major constituent of the Arp2/3 complex (composed of ACTR2, ACTR3, P41-ARC, P34-ARC, P21-ARC, P20-ARC and P16-ARC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin
  • interaction between cortactin and ACTR2, ACTR3 complex plays an important role in S1P-mediated remodeling of endothelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS