Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol C1D contributors: mct - updated : 23-08-2013
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to murine Suncor
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • exosome-associated protein and thus might regulate its functional activities
  • playing a role with MPP6 and SKIV2L2 in the recruitment of the exosome to pre-rRNA to mediate the 3' end processing of the 5.8S rRNA
  • activator of the DNA-dependent protein kinase (DNA-PK), which is essential for the repair of DNA double-strand breaks (DSBs) and V(D)J recombination
  • associated with DNA repair complex and may promote repair of UV-induced DNA damage
  • is essential for wild-type ciliary beating
  • role for C1D in coordinating the activity of specific dynein isoforms to control ciliary motility
  • C1D projection is involved in the control of interdoublet sliding velocity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex associated with the C1D projection of the central apparatus that PCDP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAX (may be to regulate TRAX/Translin complex formation)
  • C1D facilitates ERCC3 DNA repair through direct interaction with ERCC3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene major autoantigen in patients with the PM-scleroderma overlap syndrome and suggest that the use of recombinant as an autoantibody target may aid in diagnosis of the PM-scleroderma overlap syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS