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FLASH GENE
Symbol SSB contributors: mct - updated : 22-02-2008
HGNC name Sjogren syndrome antigen B (autoantigen LA)
HGNC id 11316
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RNA recognition motif
  • a C-terminal domain that contains an atypical RNA recognition motif and a short basic motif (SBM) adjacent to phosphoserine-366
  • HOMOLOGY
    interspecies homolog to murine Ssb
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III
  • can bind to nascent RNA transcripts and has also been postulated to act as an RNA polymerase III (pol III) transcription initiation and termination factor
  • playing an important role in the modulation of PAM expression, possibly by mechanisms that involve a nuclear retention and perhaps a processing of pre-PAM mRNA molecules
  • essential RNA-binding protein implicated in different aspects of RNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • cleaved by granzyme B and N-terminal La fragment (27 kD) translocated to the cytoplasm, thus leading to a novel autoantibody production during granzyme B-mediated cytotoxicity
  • CSNK2A1 is responsible for phosphorylation of SSB protein serine-366 and can modulate RPL37 5prime-terminal oligopyrimidine mRNA metabolism
  • interaction with nucleolin (at least in part responsible for nucleolar accumulation of SSB and nonphosphorylated SSB may be involved in ribosome biogenesis)
  • interacting with CCND1 (role of SSB in cell proliferation and CCND1 expression demonstrating for the first time an overexpression of the RNA-binding protein SSB in solid tumors.)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS