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FLASH GENE
Symbol ATXN10 contributors: mct - updated : 15-05-2013
HGNC name ataxin 10
HGNC id 10549
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal armadillo repeats
  • conjugated ubiquitinated
    HOMOLOGY
    interspecies homolog to murine Sca10
    Homologene
    FAMILY
  • armadillo repeat proteins
  • ataxin-10 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    basic FUNCTION
  • playing an essential role for survival of cerebellar neurons
  • having a role in pancreatic beta cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with OGT (O-linked GlcNAc transferase)
  • interacting with GNB2 (coexpression of ataxin 10 and GNB2 potently activated the Ras-MAP kinase-Elk-1 cascade, a mechanism for inducing neuritogenesis
  • IQCB1-Ataxin10 interaction
  • PLK1 is one of ATXN10 binding partners
  • cell & other
    REGULATION
    Phosphorylated by PLK1 (PLK1 phosphorylation of Ataxin-10 influences its degradation and cytokinesis, which may provide mechanistic insight to SCA10 pathogenesis)
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA10 , NPHP17
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS