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FLASH GENE
Symbol VPS28 contributors: mct - updated : 04-06-2019
HGNC name vacuolar protein sorting 28 (yeast)
HGNC id 18178
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain of VPS28 has a hydrophobic binding site on its surface that is conformationally dynamic
  • a C-terminal domain involved in interactions with other ESCRT components
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Vps28p classE
    Homologene
    FAMILY ESCRT-I complex (endosomal complexes required for transport)
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • removal of endosomal protein-ubiquitin conjugates
  • functions as a molecular switch for the GEF activity of SOS1, directing this activity toward RAC1
  • involved in sorting ubiquitinated proteins to multivesicular bodies as well as in mediating budding of retroviruses
  • functions likely as a negative modulator of the SOS1–RAS signaling events initiated by peptide growth factors including EGF
  • VPS28, VPS24, and VPS25 are required for dendrite stabilization in mature neurons
  • P
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AP1G2 specifically interacts with the ESCRT subunits VPS28 and CHMP2A
  • UBAP1, a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with TSG101, VPS28, and VPS37A
  • physically associates with SOS1 and thereby inhibits the GEF activity of SOS1 on RAS, which prevents the epidermal growth factor (EGF)-induced activation of the RAS–ERK1/2 pathway
  • blocks cyclin D1 expression, as well as DNA synthesis, induced by EGF-stimulated Erk1/2 pathway
  • )
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS