SUBCELLULAR LOCALIZATION
| plasma membrane,junction,adherens
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| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microfilament
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| intracellular,nucleus
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text
| colocalizes with afadin at adherens junctions (AJs) and was also detectable at the perinuclear regions, probably the Golgi complex |
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localizes to the basal body of primary cilia in human and murine ciliated cells |
basic FUNCTION
| actin filament (F-actin)-binding protein associated with the cytoplasmic tail of nectin, a Ca(2+)-independent immunoglobulin-like cell-cell adhesion molecule |
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may be involved in organization of the actin cytoskeleton at cell-cell adherens junctions (AJs) through afadin and alpha-actinin |
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involved in vesicle trafficking from the Golgi to the endoplasmic reticulum and through the Golgi complex by interacting with the coatomer complex |
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is a novel centrosome maturation and maintenance factor that is expressed at the onset of vertebrate development |
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preserves centrosome integrity and faithful mitosis during the rapid cleavage division of blastomeres and in somatic cells |
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centriolar satellite protein, playing a role in the assembly of primary cilia |
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is a novel targeting factor for ciliary membrane proteins cooperating with CEP290, the BBSome, and RAB8A |
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is delivered to the centrosome in a centriolar satellite-dependent manner and binds the microtubule-nucleator gamma-tubulin complex |
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is essential for ciliogenesis |
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SSX2IP-mediated microtubule anchoring is essential for proper centriole assembly and duplication |
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conserved spindle anchoring protein |
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the conserved WRAP73-SSX2IP complex plays a critical role in controlling proper spindle length and orientation |