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FLASH GENE
Symbol SSX2IP contributors: mct - updated : 04-01-2017
HGNC name synovial sarcoma, X breakpoint 2 interacting protein
HGNC id 16509
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ER retention motif
  • nuclear localization signal (NLS)
  • three coiled-coil domains
  • one P-loop motif
  • HOMOLOGY
    Homologene
    FAMILY
  • SSX family, MSD1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microfilament
    intracellular,nucleus
    text
  • colocalizes with afadin at adherens junctions (AJs) and was also detectable at the perinuclear regions, probably the Golgi complex
  • localizes to the basal body of primary cilia in human and murine ciliated cells
  • basic FUNCTION
  • actin filament (F-actin)-binding protein associated with the cytoplasmic tail of nectin, a Ca(2+)-independent immunoglobulin-like cell-cell adhesion molecule
  • may be involved in organization of the actin cytoskeleton at cell-cell adherens junctions (AJs) through afadin and alpha-actinin
  • involved in vesicle trafficking from the Golgi to the endoplasmic reticulum and through the Golgi complex by interacting with the coatomer complex
  • centriolar satellite protein, playing a role in the assembly of primary cilia
  • is a novel targeting factor for ciliary membrane proteins cooperating with CEP290, the BBSome, and RAB8A
  • is delivered to the centrosome in a centriolar satellite-dependent manner and binds the microtubule-nucleator gamma-tubulin complex
  • is essential for ciliogenesis
  • SSX2IP-mediated microtubule anchoring is essential for proper centriole assembly and duplication
  • conserved spindle anchoring protein
  • the conserved WRAP73-SSX2IP complex plays a critical role in controlling proper spindle length and orientation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WRAP73 formed a complex and partially colocalised with SSX2IP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SSX2
  • binding alpha-actinin, an F-actin-bundling protein known to be indirectly associated with E-cadherin through its direct binding to alpha-catenin
  • SSX2IP mediates the activation of RAC1 through VAV2
  • WRAP73 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component CEP135
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BSSX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in myeloid leukaemia cells.
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS