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FLASH GENE
Symbol RAB3IP contributors: npt/mct - updated : 17-06-2016
HGNC name RAB3A interacting protein (rabin3)
HGNC id 16508
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one ER retention motif
  • one coiled-coil domain
  • one nuclear localization signal (NLS)
  • the GEF domain RAB3IP display the minimal targeting machinery for recruiting their cognate RABs (RAB1A and RAB8A, respectively) to the mitochondrial membrane
  • HOMOLOGY
    interspecies homolog to rattus Rabin3
    Homologene
    FAMILY
  • SEC2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text localized to the cortical actin (Hattula 2002)
    basic FUNCTION
  • involved in mediating polarized membrane transport (Hattula 2005)
  • having exchange activity on RAB8A and RAB8B but not on RAB3A (Hattula 2002)
  • Rab8-specific activator that is connected to processes that mediate polarized membrane traffic to dynamic cell surface structures (Hattula 2002)
  • is a direct phospho-substrate of ERK1/2 in response to EGF signaling, and ERK1/2 activate RAB3IP to regulate vesicular trafficking to the plasma membrane in response to extracellular signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RAB3IP, RAB10, and the microtubule minus-end-directed kinesin KIFC3 form a peroxisome-associated complex to control the movement of peroxisomes along microtubules, enabling communication between peroxisomes and ciliary pocket membranes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SSX2
  • bind RAB8A and function as nucleotide exchange factors for Rab8 but not for RAB3A and RAB5 (Hattula 2005)
  • ASAP1 serves as a scaffold that brings together the proteins necessary for transport to the cilia including the GTP-binding protein ARF4 and the two G proteins of the Rab family--RAB11A and RAB8A--linked by the RAB8A guanine nucleotide exchange factor RAB3IP
  • components of the vesicular transport machinery, the GEF RAB3IP and the GTPase RAB8A, are interacting partners of CEP164
  • RAB11FIP3 coordinates the interactions of ASAP1 and RAB11A with RAB3IP
  • RAB11FIP3 acts synergistically with ASAP1 to direct RAB3IP in ciliary receptor targeting
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS