basic FUNCTION
| microtubule-associated protein required to maintain the spindle midzone |
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crucial role in midzone formation, indicating that cell cycle-dependent translocation of PRC1 by KIF4A is essential for midzone formation and cytokinesis |
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essential factor in controlling the spatiotemporal formation of the midzone in human cells |
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functional involvement of PRC1 during the meiotic prophase of male germ cells and regulatory role of SCMH1 for PRC1, which involves sex chromosomes |
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recruiting CLASP1 to the central spindle at early anaphase onset, to organize central spindle plasticity in mitosis |
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by combining structural flexibility and rigidity, tune microtubule associations to establish crosslinks that selectively "mark" antiparallel overlap in dynamic cytoskeletal networks |
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even in the absence of spindle bipolarity, PRC1 appears to be essential for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly, whereas KIF4A is required for limiting the length of anaphase microtubules |
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having a central role in the regulation of heritable gene silencing during differentiation and development |
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plays a key role in organizing the midzone complex |
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PRC1 and KIF4A, two microtubule-associated proteins required for midzone assembly, can tag microtubule plus ends |
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anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A |