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FLASH GENE
Symbol VTI1B contributors: mct - updated : 28-04-2012
HGNC name vesicle transport through interaction with t-SNAREs homolog 1B (yeast)
HGNC id 17793
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helical region found in SNAREs
  • HOMOLOGY
    Homologene
    FAMILY
  • VTI1 family
  • CATEGORY receptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text membrane protein type 4
    basic FUNCTION
  • vesicle docking
  • both VTI1B and STX6 function and have rate-limiting roles in TNFalpha trafficking and secretion
  • combinational SNARE proteins VAMP8 and VTI1B mediate the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential event for autophagic degradation
  • VTI1A, VTI1B, are involved in neuronal development
  • functions at late endosomes
  • CELLULAR PROCESS cell life, senescence
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text may be concerned with increased secretion of extracellular matrix and various cytokines associated with cellular senescence
    PATHWAY
    metabolism
    signaling
    a component
  • forms a snare complex with syntaxin 7, syntaxin 8 and endobrevin/VAMP-8 which functions in the homotypic fusion of late endosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLINT1 binds to VTI1B, suggesting that it may be a VTI1B-selective adaptor
  • endosomal SNARE proteins physically and functionally interact with CFTR
  • interacting with STX11 (by regulating the availability of VTI1B, STX11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS