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FLASH GENE
Symbol DOK2 contributors: mct/npt - updated : 07-04-2015
HGNC name docking protein 2, 56kDa
HGNC id 2991
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal insulin receptor substrate motif (IRS1)
  • thirteen potential tyrosine phosphorylation binding sites (PTB)
  • a putative pleckstrin homology domain (PH) at the N terminus, necessary for the tyrosine phosphorylation of Dok proteins and their negative functions in T cells (Guittard 2009)
  • six PXXP SH3 recognition motifs
  • HOMOLOGY
    intraspecies paralog to DOK1
    Homologene
    FAMILY
  • Dok family of adaptors
  • type A subfamily
  • CATEGORY adaptor , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text recruited to membrane by KITLG or PIBK
    basic FUNCTION
  • insulin receptor ligand
  • negatively regulates mitogen-activated protein kinase Erk downstream of protein-tyrosine kinases (PTKs) (Honma 2006)
  • are involved in T cell homeostasis maintenance (Guittard 2009)
  • plays an important role in integrin outside-in signaling through a physical and functional interaction with integrin alphaIIbbeta3 (Hughan 2007)
  • major tyrosine-phosphorylated protein associated to Tec, a protein tyrosine kinase expressed in T cells (Gerard 2004)
  • involved in a negative feedback regulation of Tec via a downregulation of its tyrosine phosphorylation and downstream signalling pathways including the Ras pathway (Gerard 2004)
  • suppresses lung cancer cell proliferation (Berger 2010)
  • adaptor protein that function in feedback loops to modulate tyrosine kinase signaling (Berger 2010)
  • INPP5D, DOK1 and 2 play central roles in CD4-mediated inhibitory signaling
  • DOK1, DOK2, and DOK3 cooperatively play critical anti-inflammatory roles in lung homeostasis
  • DOK1 and DOK2 differentially regulate TLR2-induced pro-inflammatory signaling in astrocytes and microglia
  • DOK1 and DOK2 proteins are involved in an intrinsic negative feedback loop downstream of NK-cell-activating receptors
  • adapter protein which is involved in hematopoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RASA1 (Ras GAP) from CML cells
  • DOK2 is able to control KLF1 expression by transcriptional regulation through directly binding to its promoter region
  • cell & other
    REGULATION
    activated by chimeric p210 bcr/abl protein
    Other regulated by LCK
    rapidly phosphorylated on tyrosine residues in platelets in response to thrombin (Hughan 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in lung adenocarcinoma (Berger 2010)
    constitutional       loss of function
    DOK1 and DOK2 deficiency induces osteopenia by activation of osteoclasts
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS