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FLASH GENE
Symbol EPN3 contributors: mct - updated : 27-04-2012
HGNC name epsin 3
HGNC id 18235
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • epsin N-terminal homology (ENTH) domain (ENTH domains comprise multiple alpha-helices folded upon each other to form a compact globular structure that has been implicated in interactions with lipids and proteins)
  • two or three ubiquitin-interacting motifs (UIMs)
  • two clathrin binding sequences
  • HOMOLOGY
    interspecies homolog to rattus Epsin
    homolog to Drosophila CG7646
    homolog to C.elegans ncs-2
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text
  • co-localized with clathrin
  • nuclear accumulation when nuclear export inhibited
  • basic FUNCTION
  • may serve an important function in activated epithelial cells during tissue morphogenesis
  • participatong in clathrin-mediated synaptic vesicle
  • endocytosis at a central synapse
  • endocytic adapter protein, regulating mitotic membrane morphology and spindle integrity (PMID;
  • epsin-induced membrane curvature is required for proper spindle morphogenesis, independent of its function in endocytosis during interphase (PMID;
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by extracellular matrix in cells following contact with fibrillar type 1 collagen
    Other downregulated following cell differentiation (expression spatially and temporally regulated)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS