protein
| binding to the cis-Golgi GOLGA2 (GM130) protein and GOLGB1, both required for ER to Golgi traffic |
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interaction with COG2 (essential for Golgi ribbon reformation after the disruption of the ribbon by USO1 KD or brefeldin A treatment and recovery by re-expression of USO1 or drug wash out, respectively) |
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USO1 plays an important role in the biogenesis and maintenance of the Golgi by interacting with the COG complex (and COG2) on the cis-Golgi in vesicular trafficking |
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Golgi organization depends on mutually interacting domains in COPB2 and USO1, suggesting that vesicle tethering at the Golgi involves USO1 binding to the COPI coat |
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interaction with GOLGA2 and GOLGB1 (giantin) resulting in Golgi fragmentation but not apoptosis |
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MIF interacts with USO1 in the cytoplasm and the stimulated secretion of MIF results in the accumulation of both proteins in supernatants, which is consistent with MIF release from cells in conjunction with USO1 |
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CREB3 was identified as a transcriptional regulator of upregulated ER-Golgi trafficking genes ARF4, COPB1, and USO1, and silencing of these genes attenuated lung colonization in breast cancer |