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FLASH GENE
Symbol TMSB10 contributors: mct - updated : 27-05-2015
HGNC name thymosin, beta 10
HGNC id 11879
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Tmsb10
Homologene
FAMILY thymosin beta family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • actin sequestring protein, playing an important role in the organization of the cytoskeleton
  • TMSB10 and TMSB4X have been implicated in sequestration of monomeric (G-) actin
  • physiological role for TMSB10 in sequestration of G-actin as well as in cancer cell motility
  • regulates actin dynamics as a cytoplasm G-actin sequestering protein
  • participates likely in the formation of the outline of the tooth root
  • stage-specific temporal and spatial expression pattern of TMSB10 in the developing tooth germ is indicative of multiple functions of TMSB10 in the developmental course from initiation to root formation of the tooth germ
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • THRSP can form heterodimers with TMSB10
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlates with lymph node metastases of papillary thyroid carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be a promising marker and a novel therapeutic target for pancreatic cancer
  • Therapy target
    ANIMAL & CELL MODELS