basic FUNCTION
| playing a role in acute inflammation |
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mediating activation of neutrophils and monocytes |
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engagement of TREM1 triggers secretion of IL8, respiratory burst and phagocytosis |
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induction of monocyte chemotactic protein-1, and TNF-alpha which induce neutrophil degranulation |
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play a role in the innate immune response against intra-amniotic infection |
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its expression in response to TLR ligands occurs secondary to downstream signaling events and the presence of TLR is necessary for the expression of TREM1 in response to their specific ligands |
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involved in the innate inflammatory response to microbial infections |
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hypoxia-inducible gene in mature dendritic cells |
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activating receptor expressed on neutrophils and monocytes that amplifies inflammation induced by stimulation of pattern-recognition receptors |
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activating receptor on inflammatory cells upregulated by microbial products |