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FLASH GENE
Symbol FBXO25 contributors: mct/npt - updated : 16-05-2011
HGNC name F-box protein 25
HGNC id 13596
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 40 AA F-box motif
  • an atypical serine residue which is crucial for the hFBX25-Skp1 binding
  • a functional F-box domain that binds to SKP1A and thereby to RBX1 and CUL1
  • HOMOLOGY
    intraspecies paralog to FBXO32
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • nuclei-specific in cardiomyocytes
  • localizes to the nucleus as a component of the nuclear body named FANDs (FBXO25-associated nuclear domains), partially colocalizes with CUL1, SKP1, ubiquitinated proteins, and the proteasome
  • basic FUNCTION
  • brain-expressed F-box protein, invoved in phosphorylated dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome, APC) and preventing mitotic exit in cystostatic factor (CSF) arrested eggs
  • F-box protein that serve as specificity factors for a family of ubiquitin ligases composed of s-phase-kinase associated protein 1, really interesting new gene-box 1, Cullin 1, and F-box protein (SCF1) that are involved in targeting proteins for destruction across the ubiquitin proteasome system
  • is cardiomyocyte-specific and acts as an ubiquitin E3 ligase to target cardiac specific transcription factors
  • has a physiological relevance in cardiac development
  • is a potential mitogen pathway regulator through ELK1 degradation
  • mediates ubiquitination and proteasomal degradation of ELK1 as well as the functional relevance of this effect in the cells
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • huntingtin protein can be a target for the nuclear FBXO25 mediated ubiquitination
  • beta-actin, physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments
  • acts as an ubiquitin E3 ligase to target cardiac transcription factors including NKX2-5, ISL1, and HAND1, indicating that cardiac protein homeostasis through FBXO25 has a pivotal impact on cardiac development
  • FBXO25 interacts and mediates ubiquitination and proteasomal degradation of the ELK1 protooncogene regulator
  • mediates ELK1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK1 pathway in response to mitogens
  • FBXO25 directly interacts with TBX5 and NKX2-5, and controls TBX5 and NKX2-5 transcriptional activity to regulate cardiomyocyte development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS