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FLASH GENE
Symbol APEX2 contributors: mct/npt - updated : 10/09/2008
HGNC name APEX nuclease (apurinic/apyrimidinic endonuclease) 2
HGNC id 17889
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila Apc
homolog to E.coli exo III
Homologene
FAMILY
  • DNA repair enzymes AP/exoA family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus
    basic FUNCTION
  • having a weak class II AP endonuclease activity
  • playing an important role in both nuclear and mitochondrial base excision repair (BER) (PCNA-dependent BER pathway in the nucleus)
  • exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity
  • playing a role as a 3'-5' exonuclease
  • CELLULAR PROCESS nucleotide, repair, base excision repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS