Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

APEX2

contributors: mct/npt - updated : 10/09/2008

HGNC name	APEX nuclease (apurinic/apyrimidinic endonuclease) 2
HGNC id	17889

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to Drosophila Apc
	homolog to E.coli exo III

Homologene

FAMILY

DNA repair enzymes AP/exoA family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,nucleus

basic FUNCTION	having a weak class II AP endonuclease activity
	playing an important role in both nuclear and mitochondrial base excision repair (BER) (PCNA-dependent BER pathway in the nucleus)
	exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity
	playing a role as a 3'-5' exonuclease

CELLULAR PROCESS

nucleotide, repair, base excision repair

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS