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FLASH GENE
Symbol RANGRF contributors: mct - updated : 20-10-2007
HGNC name RAN guanine nucleotide release factor
HGNC id 17679
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast Mog1
Homologene
FAMILY
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
text shuttles between the nucleus and the cytoplasm
basic FUNCTION
  • regulates the nuclear transport functions of RAN
  • evolutionarily conserved RAN binding protein that could play a role in regulating nuclear protein trafficking
  • functioning not only for nuclear import but also for RNA metabolism and signal transduction
  • central component of the channel complex and modulates the physiological function of SCN5A, regulating the proper expression and function of SCN5A in cardiomyocytes
  • play a regulatory role in nuclear import and export by maintaining the Ran-GTP gradient from the nuclei to the cytoplasm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text regulation of nuclear protein trafficking
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds RanGTP and stimulates guanine nucleotide release
  • co-factor for SCN5A and modulates the appropriate expression and function of SCN5A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS