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FLASH GENE
Symbol EMSY contributors: mct - updated : 02-12-2021
HGNC name EMSY transcriptional repressor, BRCA2 interacting
HGNC id 18071
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • EMSY N terminal domain (ENT)
  • a TUDOR-like domain (AGENET domain)
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • repressor protein having the capacity to bind a small epitope within the BRCA2 exon 3-encoded transcriptional activation domain and specially silencing this activity
  • playing a role at least partially in the regulation of chromatin
  • involved in DNA damage repair, genomic instability, and chromatin remoldin
  • EMSY played an oncogenic role in the progression of ovarian cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with BRCA2 (links the BRCA2 pathway to sporadic breast and ovarian cancer)
  • bind BRCA2 and inactivate the function of BRCA2, leading to the development of sporadic breast and ovarian cancers
  • ZNF131, recruits EMSY to a large number of active, H3K4me3 marked promoters
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in sporadic breast cancer and higher-grade ovarian cancer with poor prognosis
    tumoral     --over  
    in various sporadic cancers
    Susceptibility to prostate cancer and prostate cancer death
    Variant & Polymorphism SNP
  • the most significant association with prostate cancer and death is at rs12277366
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    might be a promising target for the treatment of ovarian cancer
    ANIMAL & CELL MODELS