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FLASH GENE
Symbol SLC2A11 contributors: mct - updated : 18-03-2020
HGNC name solute carrier family 2 (facilitated glucose transporter), member 11
HGNC id 14239
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve putative membrane spanning helices
  • a highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins (and SLC2A11) acts as a critical determinant of their substrate selectivity
  • HOMOLOGY
    interspecies homolog to C.elegans Lin-11
    intraspecies homolog to GLUTS
    Homologene
    FAMILY
  • sugar transporter family
  • glucose transporter subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,nucleus,nucleoplasm
    text expressed exclusively in slow-twitch muscle fibres and is unaffected by physiological and pathophysiological conditions except in primary myopathy
    basic FUNCTION
  • facilitative glucose transporter,involved in cell-mediated immunity, immunoregulation, and inflammation
  • activities of the enigmatic transporters SLC2A8 and SLC2A11 are required for proliferation and viability in myeloma, albeit because of functionalities probably distinct from whole-cell glucose supply
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by fructose
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    therapeutic strategy entailing selective SLC2A4, SLC2A11, SLC2A8 inhibition to specifically target aberrant glucose metabolism in cancer
    ANIMAL & CELL MODELS