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FLASH GENE
Symbol ZKSCAN3 contributors: mct/pgu - updated : 23-09-2010
HGNC name zinc finger with KRAB and SCAN domains 3
HGNC id 13853
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KRAB Krüppel-associated box at the N terminus
  • a SCAN box mediating self-association and oligomerization
  • a C2H2 Krüppel-type zinc finger domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila cg4971
    homolog to C.elegans cwn-2
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potential transcriptional regulator
  • regulates the expression of several genes favoring tumor progression including integrin beta 4
  • its induction represents a mechanism by which myeloma cells can induce cyclin D2 dysregulation, and contribute to disease pathogenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • specifically bind to oligonucleotides representing sequences from the CCND2 promoter, and to the endogenous promoter itself in myeloma cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS