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FLASH GENE
Symbol EIF4A2 contributors: mct - updated : 02-09-2020
HGNC name eukaryotic translation initiation factor 4A, isoform 2
HGNC id 3284
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
  • ATP binding and ATPase activity
  • a C terminal RNA helicase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic translation initiation factor
  • DEAD box protein family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • EIF4A1 and EIF4A2 are cytoplasmic, whereas EIF4A3 is nuclear-localized
  • basic FUNCTION
  • ATP-dependent RNA helicase, involved in the binding of capped mRNA to 40S subunit of ribosome and in mtDNA metabolism
  • playing a potential role in glucose homeostasis
  • EIF4A1 and EIF4A2 are required for translation initiation, but EIF4A3 participates in the exon junction complex (EJC) and functions in RNA metabolism including nonsense-mediated RNA decay (NMD)
  • ATP-dependent RNA helicase involved in mRNA translation
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • assembling with eIF4E kinase MNK1, eIF4G, PABPC1, eIF4F, eIF4B to the eukaryotic translation initiation complex
  • CDKA-eIF4A2 complex containing kinase activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to hepatitis C virus NS5B protein
  • HIV-1 requires EIF4A2 for optimal replication in human T cells
  • EIF4A2 does not inhibit CNOT7 association with the CCR4-NOT complex but instead inhibits CNOT7 activity
  • cell & other
    REGULATION
    Other EIF4A2 is modified by SUMO, with sumoylation occurring on a single residue (K226), and inability to sumoylate EIF4A2 results in impaired stress granule formation, indicating a new role for sumoylation in the stress response
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    non-small-cell lung cancer (NSCLC) patients with low EIF4A2 expression survived shorter than those with high EIF4A2 expression
    tumoral     --over  
    high expression levels of EIF4A2 are associated with a poor prognosis in esophageal squamous cell carcinoma (ESCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene to type 2 diabetes in French families
    Marker
  • could be served as a potential prognostic marker for patients with non-small-cell lung cancer (NSCLC)
  • may be used as a potential prognostic indicator in patients with ESCC
  • Therapy target
    ANIMAL & CELL MODELS