motifs/domains
| N-terminal proline-rich domain is required for scrambling activity |
|
three leucine repeats |
|
a long N terminal cytoplasmic domain, proline rich N terminal domain with multiple PXXP motifs and a PPXY motif located near the N terminus, implying the potential for interaction with SH3 or WW domain-containing protein |
|
a transmembrane region |
|
two CTH peptides (288-306 and 288-318) show that they insert through phospholipid bilayers and that the presence of cholesterol improves their affinity for lipid vesicles |
|
a Ca2+ binding motif that is a novel type of Ca2+ binding motif , and a single EF-hand-like Ca(2+)-binding motif |
|
a short extracellular tail |
|
contains an amino acid segment at the C-terminal region that shows a remarkable affinity for cholesterol, although it lacks the CRAC sequence , and also a C-terminal helix (CTH), required for membrane insertion and Ca(2+) coordination and also playing an important role in the functional conformation of PLSCR1 |
basic FUNCTION
| mediating maybe accelarated ATP-independent bidirectional transbilayer migration of phospholipids upon binding Ca2+ |
|
facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane |
|
endofacial membrane protein, which is proposed to mediate the bidirectional movement of plasma membrane phospholipids during proliferation and apoptosis |
|
physiologic regulator of PLAC8, with a functional interdependence between PLAC8 and PLSCR1 |
|
positive intracellular acute phase protein with a tissue-specific mechanism for up-regulation |
|
may play a central role in the initiation of fibrin clot formation,in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system |
|
possible role in nuclear transcription and may be contributing to post transcriptional effector pathway(s) mediating the cellular response to EGF |
|
Ca(2+)-dependent endofacial plasma membrane protein, which is tyrosine-phosphorylated in activated cells |
|
novel amplifier of MS4A2 signaling that acts selectively on the LYN-initiated LAT/PLCG1/calcium axis, resulting in potentiation of a selected set of mast cell responses |
|
may, in part, contribute to the prothrombotic tendency in systemic lupus erythematosus |
|
PLSCR1 prolongs the mitotic expansion of granulocyte precursors during CSF3-induced granulopoiesis |
|
role of specific lipid reorganization and calcium-dependent PLSCR1 activity in neuroendocrine compensatory endocytosis |
|
intrinsic membrane protein catalyzing transbilayer phospholipid transfer in the absence of ATP |
|
mediate bidirectional scrambling of phospholipids in a Ca(2+)-dependent manner |
|
role of PLSCR1 in negatively regulating trophoblast fusion |
|
Ca2+-dependent protein known to scramble phospholipids in the plasma membrane resulting in loss of membrane asymmetry |
|
PLSCR1 expression is regulated by low pH, providing insights into the role of PLSCR1 in cancer progression |
|
protein that regulates bilayer asymmetry, and involved in altering the phospholipids of endothelial cells during hypoxia, a component of ischemia, leading to APOH and IgM binding and subsequent lipid-mediated, inflammatory responses |
|
PLSCR1 positively regulates hepatic carcinoma cell proliferation and migration through interacting with MDK, thus deepening our understanding on the regulation of midkine during hepatic carcinoma growth and metastasis |
|
type II endofacial membrane protein which mediates bi-directional transport of phospholipids across the plasma membrane |
|
acts as a multifunctional signaling molecule rather than functioning as scramblase |
|
shows a metal dependent nuclease activity which could play a role in key cellular processes |
|
distributes lipids non-selectively between the cellular membrane leaflets |