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FLASH GENE
Symbol KLF3 contributors: mct - updated : 28-10-2010
HGNC name Kruppel-like factor 3 (basic)
HGNC id 16516
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PVDLS sequence required for contact with GTBP1
  • a highly conserved 81 AA DNA binding domain
  • a stretch of basic residues
  • three Krüppel related zinc fingers at the C terminus
    • HOMOLOGY
    interspecies homolog to murine Klf3
    Homologene
    FAMILY
  • CACCC binding zinc finger family
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional corepressor with CTBP1 involved in hematopoiesis
  • transcriptional regulator of muscle genes, which may play an important role in muscle differentiation
  • CACCC box binding factor in erythroid cells, and bind C(A/C)CACCC with particularly high affinity
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text hematopoietic differentiation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding CACCC box containing proteins
    RNA
    small molecule
    protein
  • CTBP1 acting with KLF3 as a repressor for a number of transcription factors
  • associate with CTBP2 and FHL3, which mediate its repressive effects on gene transcription
  • binds the CEBPA promoter and both are implicated in controlling adipogenesis
  • represses the Klf8 (Krüppel-like Factor 8) gene
  • interacting with SRF (physically associate and synergize in transactivating the CKM (Muscle creatine kinase) promoter independently of SRF binding to CArG motifs
    • cell & other
    REGULATION
    activated by KLF1 (directly activates KLF3)
    induced by erythroid Krüppel like factor EKLF (KLF1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to progressive myeloproliferative disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    BKLF deficient mice exhibit a myeloproliferative disorder