basic FUNCTION
| broad spectrum coactivator |
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a tissue-specific, kinase-regulated nuclear receptor coactivator that interacts with the DNA-binding domains of nuclear receptors |
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regulate steroid hormone receptor-mediated transcription and to stimulate homologous recombination in DNA repair |
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PSMC3IP-MND1 stabilizes the DMC1-single-stranded DNA (ssDNA) filament and promotes the capture of the double-stranded DNA partner by the recombinase filament to assemble the synaptic complex |
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PSMC3IP-MND1 is a 'molecular trigger' of RAD51 DNA strand exchange |
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RAD51 and the PSMC3IP-MND1 heterodimer, are essential for homologous chromosome synapsis during meiosis |
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PSMC3IP and EPSTI1 are able to modulate the extrinsic apoptotic pathway in estrogen receptor positive and triple negative breast cancer cell lines |
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PSMC3IP/MND1 is expressed in somatic tissues, primary human fibroblasts and cell lines, and that it functions in conjunction with the RAD51 recombinase to repair damaged telomeres via the alternate lengthening of telomeres mechanism |
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is a steroid hormone receptor coactivator and a crucial factor in DNA repair |