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FLASH GENE
Symbol PSMC3IP contributors: mct/npt - updated : 25-10-2016
HGNC name PSMC3 interacting protein
HGNC id 17928
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several phosphorylation sites
  • a leucine zipper required for its dimerization
  • C -terminal basic region required for efficient DNA binding and also essential for its homologous pairing stimulation activity
  • HOMOLOGY
    intraspecies homolog to GT198
    Homologene
    FAMILY
  • HOP2 family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text proteasome
    basic FUNCTION
  • broad spectrum coactivator
  • a tissue-specific, kinase-regulated nuclear receptor coactivator that interacts with the DNA-binding domains of nuclear receptors
  • regulate steroid hormone receptor-mediated transcription and to stimulate homologous recombination in DNA repair
  • PSMC3IP-MND1 stabilizes the DMC1-single-stranded DNA (ssDNA) filament and promotes the capture of the double-stranded DNA partner by the recombinase filament to assemble the synaptic complex
  • PSMC3IP-MND1 is a 'molecular trigger' of RAD51 DNA strand exchange
  • RAD51 and the PSMC3IP-MND1 heterodimer, are essential for homologous chromosome synapsis during meiosis
  • PSMC3IP and EPSTI1 are able to modulate the extrinsic apoptotic pathway in estrogen receptor positive and triple negative breast cancer cell lines
  • PSMC3IP/MND1 is expressed in somatic tissues, primary human fibroblasts and cell lines, and that it functions in conjunction with the RAD51 recombinase to repair damaged telomeres via the alternate lengthening of telomeres mechanism
  • is a steroid hormone receptor coactivator and a crucial factor in DNA repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the multicatalytic proteinase complex
  • part of PSMC3IP/MND1 complex that may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis (Enomoto 2006)
  • evolutionarily conserved PSMC3IP/MND1 complex is a key cofactor for the meiosis-specific recombinase DMC1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhancing the inhibitory actin of PSMC3 (TBP1) in HIV-1 Tat-madiated transactivation in vitro
  • interacting with the DNA-binding domains of nuclear receptors
  • interacting with PSMC3 (directly PSMC3 binds AR and might participate in AR-mediated transcriptional activation in cooperation with PSMC3IP) (Satoh 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) XXGD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    are present in breast and ovarian cancer families
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PSMC3IP expression is a specific marker of mutant breast tumor stroma and has the potential to facilitate diagnosis and targeted treatment of human breast cancer
  • Therapy target
    ANIMAL & CELL MODELS