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FLASH GENE
Symbol GOLGA1 contributors: mct - updated : 03-03-2015
HGNC name golgi autoantigen, golgin subfamily a, 1
HGNC id 4424
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large coiled coil domain
  • a RAB6 interaction domain
  • a C terminal Golgi localization domain (GLD) called the GRIP domain, and GRIP domains of GOLGA4 and GOLGA1 bind discriminately to distinct membrane subdomains of the TGN
    • HOMOLOGY
    Homologene
    FAMILY
  • ezrin/radixin/moesin family
  • golgin family
    • CATEGORY antigen , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • GOLGA1, GOLGA4 are targeted to the Golgi membrane through their GRIP domains
    • basic FUNCTION
  • involved in RAB6 regulated membrane-tethering events
  • GOLGA1, GOLGA4, GCC1, GCC2 can self-associate to form homodimers exclusively
  • selective and essential component of the tubulovesicular carriers transporting CDH1 out of the TGN
  • may be involved in the maturation of the virus core and, potentially, the virus membrane
  • trans-Golgi network membrane protein, essential for virus replication
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • Golgi complex antigen targeted by autoantibodies associated with Sjögren syndrome
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARL1 through GRIP domain
  • interaction between RAB2A and the ARL1-regulated scaffolding proteins GOLGA4 and GOLGA1 might be necessary for RAB2A to be released from the Golgi for further vesicular trafficking
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS