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FLASH GENE
Symbol VEZT contributors: mct/pgu - updated : 25-08-2011
HGNC name vezatin, adherens junctions transmembrane protein
HGNC id 18258
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal region of alpha-catenin
  • two adjacent transmembrane domains, and cytoplasmic N- and C-terminal regions
  • a long intracellular domain binding to myosin VIIA
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    text
  • in the inner ear sensory hair cells vezatin is, in addition, concentrated at another membrane-membrane interaction site, namely at the fibrillar links interconnecting the bases of adjacent stereocilia
  • localized at dendrites as well as cell bodies
  • basic FUNCTION
  • plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life
  • associates with actin filaments at cell-cell junctions, and is required for the sound resilience of cochlear hair cells
  • may regulate dendritic formation as a downstream effector of ARF6
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
  • miR-43c directly targets adherens junctions (VEZT) and suppresses VEZT protein expression
  • small molecule
    protein
  • bridges myosin VIIA to the cadherin-catenins complex
  • interactions between GPR98, WHRN, USH2A, VEZT further support their involvement in a molecular complex associated with the ankle links and scaffolded by whirlin
  • directly interacts with radixin in its actin-binding conformation
  • novel binding partner of active GTP-bound ARF6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS