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FLASH GENE
Symbol ELOA contributors: mct - updated : 03-06-2020
HGNC name elongin A
HGNC id 11620
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal TFS2N motif, approximately 120 amino acid dispensable for its transcriptional activity
  • 1 F-box domain
    • mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text colocalized with EXO1 to the cell nucleus
    basic FUNCTION
  • transcriptionally active subunit of the elongin complex
  • increasing the average rate of RNA chain elongation across DNA templates
  • ELOA also acts as a component of a cullin-RING ligase that can target stalled pol II for ubiquitylation and proteasome-dependent degradation
  • role for ELOA in the regulation of stress response genes
  • performs dual functions in cells as a component of RNA polymerase II (Pol II) transcription elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase
  • in unstressed cells, ELOA is predominately present as part of Pol II elongation factor Elongin
  • ELOA ubiquitin ligase and the ERCC6 protein function together in a common pathway in response to Pol II stalling and DNA damage
    • CELLULAR PROCESS nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • catalyzing subunit of the transcription elongation factor associated the BC complex SIII, TCEB3A including TCEB2 and TCEB1 (elongin BC)
  • heterotrimer of an A (A1, A2 or A3), B and Csubunit
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • elongin BC
  • ERCC6 protein promotes stable recruitment of the ELOA ubiquitin ligase to sites of DNA damage
  • Polycomb Repressive Complex 2 methylates ELOA to regulate transcription
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Eloa-deficient embryos exhibit abnormalities in the formation of both cranial and spinal nerves and ELOA(-/-) embryonic stem cells (ESCs) show a markedly decreased capacity to differentiate into neurons