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FLASH GENE
Symbol CPM contributors: mct - updated : 24-04-2020
HGNC name carboxypeptidase M
HGNC id 2311
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • hydrophobic domains at the N and C termini
  • a conserved catalytic domain including six glycosylation sites
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • carboxypeptidase M cleaving basic C terminal amino acids in monocyte to macrophage differentiation
  • membrane-bound zinc-dependent protease that cleaves C-terminal basic residues, such as arginine or lysine, from peptides/proteins 1)
  • likely a cellular player in lipid uptake and/or metabolism of activated macrophages (MAs) by promoting foam cell formation
  • could likely promote foam cell formation by acting in the lipid regulation process of macrophages
  • inhibition of CPM, the key enzyme involved in the biosynthesis of BDKRB1 agonists, could exert the same beneficial effects to BDKRB1 antagonism in insulin resistance
  • is a glycosylphosphatidylinositol anchored enzyme that plays an important role in the kallikrein-kinin system (KKS)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • activating peptide hormones at local tissue sites, before or after binding to their ligands
  • close relationship of BDKRB1 and CPM on the membrane is required for efficiently generatingoles in inflammation
  • spatial proximity between ACE and the endogenous CPM BDKRB1 signals, which play important r enables an ACE-evoked release of CPM
  • BDKRB1 positively modulates both CPM expression and activity, suggesting that CPM-BDKRB1 interaction in membrane microdomains might affect enzyme activity, beyond interfering in receptors signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several tumor tissues
    tumoral     --over  
    in renal clear cell carcinomas
    tumoral   amplification    
    in well-differentiated liposarcomas/atypical lipomatous tumor
    Susceptibility to silicosis
    Variant & Polymorphism other
  • rs12812500 variant of the CPM gene may increase silicosis susceptibility
  • Candidate gene
    Marker
  • CPM is a novel marker in lipid uptake and/or metabolism of activated macrophages (MAs) by promoting foam cell formation
  • identification of CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    therapeutic target in insulin resistance
    ANIMAL & CELL MODELS