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FLASH GENE
Symbol SLC4A8 contributors: mct - updated : 08-04-2014
HGNC name solute carrier family 4, sodium bicarbonate cotransporter, member 8
HGNC id 11034
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal PDZ-interacting motifs
  • HOMOLOGY
    interspecies homolog to murine Ncbe
    intraspecies homolog to SLC4A5
    Homologene
    FAMILY
  • anion exchanger (TC 2.A.31) family
  • SLC4 family of bicarbonate transporters
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • is in most glutamatergic axon terminals, and is also present in the terminals of parvalbumin-positive GABAergic cells
  • basic FUNCTION
  • playing an essential role in maintaining sensory cells integrity in both visual and auditory systems
  • having inorganic anion exchanger activity
  • is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons
  • potential role in mediating substantial Na+ reabsorption in the cortical collecting duct (CCD)
  • modulates potentially glutamate release in a pH-dependent manner
  • modulate excitatory neurotransmission in hippocampus
  • can regulate glutamatergic transmission throughout the brain, and is a possible regulator of GABAergic neurotransmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CA2 interacts at high affinity with the C-terminal (Ct) domains of SLC4A8, but can bind to GST-SLC4-Ct fusion proteins only when the CA2 is immobilized and the fusion protein is soluble, and not vice versa
  • cell & other
    REGULATION
    Other its activity is inhibited by PRKACA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS