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FLASH GENE
Symbol RNF19A contributors: npt - updated : 12-05-2005
HGNC name ring finger protein 19A
HGNC id 13432
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an IBR (in between RING fingers) motif at the N terminus
  • two RING-finger motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • RING finger type ubiquitin ligase family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text localized in Lewy bodies
    basic FUNCTION
  • mediating ubiquitination of cellular proteins
  • may be involved in the pathogenic process of Parkinson disease and Lewy bodies formation by ubiquitylation of synphilin-1 (SNCAIP)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes
  • binding and ubiquitylating synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of Lewy-Bodies
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS