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FLASH GENE
Symbol RBBP7 contributors: mct/npt - updated : 04-02-2009
HGNC name retinoblastoma binding protein 7
HGNC id 9890
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six WD40 repeats
  • HOMOLOGY
    interspecies homolog to murine Rbbp7
    homolog to yeast Mis16
    intraspecies homolog to highly to RBBP4
    Homologene
    FAMILY
  • WD repeat RBAP46/RBAP48/MSI1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • histone chaperones that play key roles in establishing and maintaining chromatin structure (Murzina 2008)
  • required with RBBP4 for the recruitment of CENPA to the kinetochores
  • associated with chromatin remodeling, histone deacetylation, and transcription repression, as proteins associated with the DNA-bound ESR1 (Creekmore 2008)
  • having a role in regulating gene expression (Creekmore 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of PRC2 complex containing four core components: EZH2, EED, SUZ12, and RBBP7
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with ESR1 (modulates estrogen responsiveness in a gene-specific manner) (Creekmore 2008)
  • RBBP4-MTA1 interaction is essential for the integration of RBBP7/RBBP4 into the NuRD complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS