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FLASH GENE
Symbol GLMN contributors: mct - updated : 08-09-2015
HGNC name glomulin, FKBP associated protein
HGNC id 14373
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • playing a role in differentiation of vascular smooth muscle cells and in vascular morphogenesis especially in cutaneous veins
  • important role for glomulin in blood vessel development and/or maintenance
  • adopts a HEAT-like repeat fold that tightly binds the E2-interacting surface of RBX1, inhibiting CRL-mediated chain formation by the E2 CDC34
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component complex between GLMN, RBX1, and a fragment of CUL1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with FK506-binding proteins (FKBPs) such as FKBP1A, FKBP4
  • GLMN binds directly to the RING domain of RBX1 and inhibits its E3 ubiquitin ligase activity
  • GLMN modulates the E3 activity of CRL1(FBXW7)
  • functional connection between GLMN and RBX1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GVM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS