protein
| VAMP1, VAMP2 |
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interacting with VAPB and ATF6 |
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interact directly with components of ER homeostatic and stress signalling systems and may therefore be parts of a previously unidentified regulatory pathway (mis-function of such regulatory systems may contribute to the pathological mechanisms of degenerative motor neuron disease) |
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GLTP interacting with VAPA |
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SLC26A5 appears to modify the expression of VAPA protein in outer hair cells (OHC), and VAPA could be involved in SLC26A5 transportation inside OHCs and may facilitate the targeting of this abundant OHC protein to the plasma membrane |
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partners of CLN8 are VAPA, C14orf1/hERG28, STX8, GABARAPL2, BNIP3 and BNIP3L proteins and are associated with biologically relevant processes such as synthesis and transport of lipids, vesicular/membrane trafficking, autophagy/mitophagy and apoptosis |
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VAPA, VAPB are endoplasmic reticulum (ER)-resident integral membrane protein that controls a nonvesicular mode of ceramide and cholesterol transfer from the ER to the Golgi complex by interacting with COL4A3BP and oxysterol-binding protein (OSBP), respectively |