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FLASH GENE
Symbol RPLP1 contributors: SGE/npt - updated : 11-06-2010
HGNC name ribosomal protein, large, P1
HGNC id 10372
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
conjugated PhosphoP
mono polymer pentamer
HOMOLOGY
interspecies homolog to murine Rplp1 (97.4pc)
homolog to rattus Rplp1 (98.2pc)
Homologene
FAMILY
  • ribosomal protein L12P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • playing an important role in the elongation step of protein synthesis
  • modulating with P2 the cytoplasmic translation by influencing the interaction between subunits, thereby regulating the rate of cell proliferation (Martinez-Azorin 2008)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit (60S subunit)
  • can interact with P0 and P2 to form a pentameric complex (P1 and P2 dimers, PO monomer)
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS