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FLASH GENE
Symbol KTN1 contributors: mct - updated : 11-10-2023
HGNC name kinectin 1 (kinesin receptor)
HGNC id 6467
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear localization signal (NLS)
  • interspersed heptad repeats
  • residues 7-29 of kinectin are sufficient for targeting to the ER membrane but insufficient for remaining on the ER
  • HOMOLOGY
    Homologene
    FAMILY ser/thr protein kinase family, iKAPPAb kinase subfamily
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • large integral ER membrane protein, phosphorylating inhibitors of NF-kappa-b thus leading to the dissociation of the inhibitor/NF-kappa-b complex and ultimately the degradation of the inhibitor
  • KTN1-mediated endoplasmic reticulum dynamics supports focal adhesion growth in the cellular lamella
  • receptor for kinesin involved in kinesin-driven vesicle
  • KTN1 may play a functional role in the development of ADHD
  • promotes the occurrence and deterioration of HCC by mediating cell survival, migration, invasion, cell cycle activation, and apoptotic inhibition
  • KTN1 preferentially binds perinuclear polyglutamylated microtubules with long glutamate chains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with mavs/IPS1
  • RAB18 regulates likely KTN1 transport toward the cell surface to form ER-FA contacts, thus promoting focal adhesions (FAs) growth and cell migration during chemotaxis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly correlated with poorer prognosis of Hepatocellular carcinoma (HCC) patients
    tumoral     --over  
    in breast cancer, and Triple-negative breast cancer (TNBC) patients with high KTN1 expression have poor prognosis
    Susceptibility to attention deficit hyperactivity disorder (ADHD)
    Variant & Polymorphism other
  • KTN1 variants were significantly associated with ADHD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    may be a therapeutic target in HCC patients
    cancerreproductivebreast
    KTN1 may be a potential molecular target for the development of TNBC treatment
    ANIMAL & CELL MODELS