basic FUNCTION
| RNA editing enzyme having roles in growth or cell cycle control |
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potent inhibitor of LTR-retrotransposon function ( |
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may influence the development of tumors (Vartanian 2008) |
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inhibits the replication of the parvovirus adeno-associated virus (Narvaiza 2009) |
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deaminates foreign double-stranded DNA cytidines to uridines (Stenglein 2010) |
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can lead to induction of DNA breaks and activation of damage responses in a deaminase-dependent manner ( |
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in contrast to the processive APOBEC3G, did not appear to deaminate ssDNA with high processivity and was less effective in causing HIV gene inactivation |
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APOBEC3A deaminations induce mostly conservative amino acid changes, suggesting that most somatic hypermutation events would not lead to gene inactivation |
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is a myeloid lineage-specific DNA cytosine deaminase with a role in innate immunity to foreign DNA |
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APOBEC3A induced G1 phase cell cycle arrest and triggered several members of the intrinsic apoptosis pathway |
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is a single-domain cytidine deaminase that converts deoxycytidine residues to deoxyuridine in single-stranded DNA (ssDNA) |
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lacks strong antiviral activity against lentiviruses but is a potent inhibitor of adeno-associated virus and endogenous retroelements |
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APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages |
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APOBEC3A- and APOBEC3B-induced mutagenesis primarily results from the deamination of the lagging strand template during DNA replication |
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APOBEC3 proteins function within the innate immune system by mutating DNA of viral genomes and retroelements to restrict infection and retrotransposition |
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APOBEC3A (A3A) expression leads to DNA damage in replicating cells but this is reduced in quiescent cells |
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its expression caused ATR-dependent phosphorylation of CHEK1 and cell-cycle arrest, consistent with replication checkpoint activation |