Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TNR contributors: mct - updated : 05-02-2015
HGNC name tenascin R (restrictin, janusin)
HGNC id 11953
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine-rich segment,
  • 4,5 EGF-like repeats
  • 9 fibronectin type III-like repeats
  • a fibrinogen-like sequence
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine loop-tail,putatively
    Homologene
    FAMILY tenascin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text extracellular matrix
    basic FUNCTION
  • inhibitor of CD3-mediated T cell interaction
  • extracellular neural recognition molecule
  • TNC and TNR play antagonistic roles for differentiation and comparably inhibit morphologic maturation
  • is an extracellular matrix glycoprotein that is restricted to the central nervous system, where it acts as a multifunctional and versatile molecule
  • potential role for tenascin-R in corticogenesis
  • TNC and tenascin-R (TNR) play important roles in cell proliferation and migration, fate determination, axonal pathfinding, myelination, and synaptic plasticity
  • role of TNR in brain development and cognition
  • importance of TNR in the regulation of hippocampal neurogenesis, suggesting that TNR acts through distinct direct and indirect mechanisms during development and in the adult
  • TNC and tenascin-R (TNR), regulate differentiation and migration, in addition to neurite outgrowth and survival in numerous types of neurons and mesenchymal progenitor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text central nervous system development, axon guidance
    PATHWAY
    metabolism
    signaling
    a component
  • aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with fibronectin-dependent cell attachment and interaction
  • TNC and TNR interfered with the activation of the small GTPase RHOA
  • TNR is likely expressed in a subset of astrocytes and contributes to glutamate homeostasis by regulating astrocytic SLC1A3 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in a child with intellectual disability and transient choreoathetosis
    tumoral     --over  
    in pilocytic astrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS